Alternative splicing modulates the frequency-dependent response of CaMKII to Ca(2+) oscillations.

@article{Bayer2002AlternativeSM,
  title={Alternative splicing modulates the frequency-dependent response of CaMKII to Ca(2+) oscillations.},
  author={K. Ulrich Bayer and Paul De Koninck and Howard F Schulman},
  journal={The EMBO journal},
  year={2002},
  volume={21 14},
  pages={3590-7}
}
Ca(2+) oscillations are required in various signal trans duction pathways, and contain information both in their amplitude and frequency. Remarkably, the Ca(2+)/calmodulin(CaM)-dependent protein kinase II (CaMKII) can decode such frequencies. A Ca(2+)/CaM-stimulated autophosphorylation leads to Ca(2+)/CaM-independent (autonomous) activity of the kinase that outlasts the initial stimulation. This autonomous activity increases exponentially with the frequency of Ca(2+) oscillations. Here we show… CONTINUE READING