Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta.

@article{Mukai2002AlternativeSI,
  title={Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta.},
  author={Fumiko Mukai and Koichi Ishiguro and Yumiko Sano and Shinobu C. Fujita},
  journal={Journal of neurochemistry},
  year={2002},
  volume={81 5},
  pages={1073-83}
}
Glycogen synthase kinase 3 (GSK3) plays important roles in Wnt and insulin signaling, cell fate determination, and Alzheimer-like tau phosphorylation. We discovered an isoform of tau protein kinase I (TPKI)/GSK3beta with a 13 amino acid insert in the catalytic domain owing to alternative splicing. The alternative transcripts were found in the brains of the mouse, rat and human, with highly conserved sequences. The variant protein, named TPKI2/GSK3beta2, was abundant in the brain… CONTINUE READING

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