Alternative splicing in human tumour viruses: a therapeutic target?

  title={Alternative splicing in human tumour viruses: a therapeutic target?},
  author={Hegel R Hernandez-Lopez and Sheila V Graham},
  journal={The Biochemical journal},
  volume={445 2},
Persistent infection with cancer risk-related viruses leads to molecular, cellular and immune response changes in host organisms that in some cases direct cellular transformation. Alternative splicing is a conserved cellular process that increases the coding complexity of genomes at the pre-mRNA processing stage. Human and other animal tumour viruses use alternative splicing as a process to maximize their transcriptomes and proteomes. Medical therapeutics to clear persistent viral infections… CONTINUE READING
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