Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor.

@article{Malosio1991AlternativeSG,
  title={Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor.},
  author={Maria Luisa Malosio and Gabriele Grenningloh and Jochen Kuhse and Volker Schmieden and Bertram Schmitt and Philippe Prior and Heinrich Betz},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 4},
  pages={2048-53}
}
The inhibitory glycine receptor (GlyR) in mammalian spinal cord displays pharmacological and molecular heterogeneity of its strychnine binding alpha subunit. Here, cDNAs were isolated which encode a variant (alpha ins 1) of the rat GlyR alpha 1 subunit that contains eight additional amino acids in its putative cytoplasmic domain. Analysis of the corresponding genomic sequence showed that alpha ins 1 transcripts result from alternative splice acceptor site selection. S1 nuclease protection… CONTINUE READING
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