Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum.

@article{Kanumilli2006AlternativeSG,
  title={Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum.},
  author={Srinivasan Kanumilli and Elizabeth W Tringham and Claire Elizabeth Payne and Jonathan R B Dupere and Kanamarlapudi Venkateswarlu and Maria M. Usowicz},
  journal={Physiological genomics},
  year={2006},
  volume={24 2},
  pages={86-96}
}
P/Q-type calcium channels control many calcium-driven functions in the brain. The CACNA1A gene encoding the pore-forming CaV2.1 (alpha1A) subunit of P/Q-type channels undergoes alternative splicing at multiple loci. This results in channel variants with different phenotypes. However, the combinatorial patterns of alternative splice events at two or more loci, and hence the diversity of CaV2.1 transcripts, are incompletely defined for specific brain regions and types of brain neurons. Using RT… CONTINUE READING
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