Alternative splicing directs the expression of two D2 dopamine receptor isoforms

@article{Giros1989AlternativeSD,
  title={Alternative splicing directs the expression of two D2 dopamine receptor isoforms},
  author={Bruno Giros and Pierre Sokoloff and M. P. Martres and Jean-François Riou and Laurent Jean Emorine and J D Schwartz},
  journal={Nature},
  year={1989},
  volume={342},
  pages={923-926}
}
DOPAMINE receptors are classified into Dl and D2 subtypes on the basis of their pharmacological properties and the intracellular responses they mediate1. The cerebral D2 dopamine receptor is the target of drugs used to alleviate the main symptoms of schizophrenia2–4. Although it is considered to be a single molecular entity, there is evidence that multiple D2-receptor subtypes exist5,6. A complementary DNA encoding a D2 receptor has recently been cloned7 and the deduced 415-amino-acid sequence… CONTINUE READING

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