Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase

Abstract

Many human tRNA synthetases evolved alternative functions outside of protein synthesis. These functions are associated with over 200 splice variants (SVs), most of which are catalytic nulls that engender new biology. While known to regulate non-translational activities, little is known about structures resulting from natural internal ablations of any… (More)
DOI: 10.1093/nar/gkw002

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