Alternative splicing at C terminus of Ca(V)1.4 calcium channel modulates calcium-dependent inactivation, activation potential, and current density.

@article{Tan2012AlternativeSA,
  title={Alternative splicing at C terminus of Ca(V)1.4 calcium channel modulates calcium-dependent inactivation, activation potential, and current density.},
  author={Gregory Tan and Dejie Yu and Juejin Wang and Tuck Wah Soong},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 2},
  pages={
          832-47
        }
}
The Ca(V)1.4 voltage-gated calcium channel is predominantly expressed in the retina, and mutations to this channel have been associated with human congenital stationary night blindness type-2. The L-type Ca(V)1.4 channel displays distinct properties such as absence of calcium-dependent inactivation (CDI) and slow voltage-dependent inactivation (VDI) due to the presence of an autoinhibitory domain (inhibitor of CDI) in the distal C terminus. We hypothesized that native Ca(V)1.4 is subjected to… CONTINUE READING
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Retinoschisin Facilitates the Function of L-Type Voltage-Gated Calcium Channels

  • Front. Cell. Neurosci.
  • 2017
VIEW 16 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Calmodulin regulates Cav3 T-type channels at their gating brake

  • The Journal of biological chemistry
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND

Alternative splicing and nonsense-mediated mRNA decay enforce neural specific gene expression

  • International Journal of Developmental Neuroscience
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-8 OF 8 REFERENCES

novel calcium channel modulator essential for initiation of neural plate development Nature Commun

C Papanayotou, Id Almeida, +11 authors Calfacilitin
  • novel calcium channel modulator essential for initiation of neural plate development Nature Commun
  • 2013

Alternative Splicing at C-terminus of Ca V 1.4 Calcium Channel Modulates Calcium-Dependent Inactivation, Activation Potential and Current Density

Gm Tan, D Yu, Wang J Soong, Tw
  • J Biol Chem
  • 2012

RNA editing of the IQ domain in Ca v 1.3 channels modulates their Ca 2+ -dependent inactivation

H Huang, Bz Tan, +10 authors Tw Soong
  • NeuronBiology
  • 1000