Alternative splicing and genome complexity

@article{Brett2002AlternativeSA,
  title={Alternative splicing and genome complexity},
  author={David Brett and Heike Pospisil and Juan Valc{\'a}rcel and Jens G. Reich and Peer Bork},
  journal={Nature Genetics},
  year={2002},
  volume={30},
  pages={29-30}
}
Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals. 
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TLDR
How alternative splicing has contributed to the evolution of modern genomes is considered, and constraints on evolution associated with alternative splice sites are discussed that might have important medical implications.
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Progress in establishing the full repertoire of functionally relevant transcript variants generated byAlternative splicing, the specific roles of such variants in normal and disease physiology, and how alternative splicing is coordinated on a global level to achieve cell- and tissue-specific functions are summarized in this review.
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