Alternative splicing and biological heterogeneity in prostate cancer

  title={Alternative splicing and biological heterogeneity in prostate cancer},
  author={Prabhakar Rajan and David J. Elliott and Craig N. Robson and Hing Y Leung},
  journal={Nature Reviews Urology},
The biological diversity of prostate cancer confounds standardization of therapy. Advances in molecular profiling suggest that differences in the genetic composition of tumors significantly contribute to the complexity of the disease. Alternative pre-mRNA splicing is a key genetic process underlying biological diversity. During alternative splicing, coding and noncoding regions of a single gene are rearranged to generate several messenger RNA transcripts yielding distinct protein isoforms with… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 41 extracted citations


Publications referenced by this paper.
Showing 1-10 of 64 references

estimating the benefits of psA screening

A. J. vickers, Lilja, H. prostate cancer
Nat. Rev. Urol. 6, 301–303 • 2009

from discovery to daily clinical practice

tomlins, s. A. et al. ETS gene fusions in prostate cancer
Eur. Urol. doi:10.1016/ j.eururo.2009.04.036 • 2009

towards a new understanding

Witte, J. s. prostate cancer genomics
Nat. Rev. Genet. 10, 77–82 • 2009

Similar Papers

Loading similar papers…