Alternative splicing and biological heterogeneity in prostate cancer

@article{Rajan2009AlternativeSA,
  title={Alternative splicing and biological heterogeneity in prostate cancer},
  author={Prabhakar Rajan and David J. Elliott and Craig N. Robson and Hing Y Leung},
  journal={Nature Reviews Urology},
  year={2009},
  volume={6},
  pages={454-460}
}
The biological diversity of prostate cancer confounds standardization of therapy. Advances in molecular profiling suggest that differences in the genetic composition of tumors significantly contribute to the complexity of the disease. Alternative pre-mRNA splicing is a key genetic process underlying biological diversity. During alternative splicing, coding and noncoding regions of a single gene are rearranged to generate several messenger RNA transcripts yielding distinct protein isoforms with… CONTINUE READING

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