Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain

@article{Nelms1999AlternativeSG,
  title={Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain},
  author={Keats A. Nelms and Thomas J. O’Neill and Shiqing Li and Stevan R. Hubbard and Thomas A. Gustafson and William E. Paul},
  journal={Mammalian Genome},
  year={1999},
  volume={10},
  pages={1160-1167}
}
Abstract. The SH2-B protein is an SH2-domain-containing molecule that interacts with a number of phosphorylated kinase and receptor molecules including the insulin receptor. Two isoforms of the SH2-B have been identified and have been proposed to arise through alternate splicing. Here we have identified a third isoform of the SH2-B protein, SH2-Bγ, that interacts specifically with the insulin receptor. This interaction required phosphorylation of residue Y1146 in the triple tyrosine motif… 

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