Alternative site of implantation affects tumor malignancy and metastatic potential in mice: its comparison to the flank model.

@article{Speroni2009AlternativeSO,
  title={Alternative site of implantation affects tumor malignancy and metastatic potential in mice: its comparison to the flank model.},
  author={Luc{\'i}a Speroni and Victoria de los Angeles Bustuoabad and Julieta Gasparri and Nadia S Chiaramoni and Mar{\'i}a Cristina Taira and Ra{\'u}l Alejandro Ruggiero and Silvia Del Valle Alonso},
  journal={Cancer biology & therapy},
  year={2009},
  volume={8 4},
  pages={375-9}
}
MC-C fibrosarcoma and B16F0 melanoma tumors were implanted intradermally in the dorsal region of the foot of mice. Tumor progression was compared to standard implantation in the flank. Although foot tumors only reached 13% (MC-C) and 25% (B16F0) of the mean volume of flank tumors, a more malignant phenotype in terms of histology and survival rate was observed in this type of tumors. Moreover, lung metastases were only detected in hosts bearing foot tumors, in contrast to MC-C and B16F0… CONTINUE READING

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