Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis.

@article{Yang2003AlternativePA,
  title={Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis.},
  author={Li V. Yang and Henry H Heng and Junmei Wan and Cherie M Southwood and Alexander Gow and Li Li},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2003},
  volume={228 4},
  pages={606-16}
}
Hemogen is a nuclear protein encoded by HEMGN (also known as hemogen in mouse, EDAG in human and RP59 in rat). It is considered to be a hematopoiesis-specific gene that is expressed during the ontogeny of hematopoiesis. Herein, we characterize two distinct splicing variants of HEMGN mRNA with restricted expression to hematopoietic cells and to round spermatids in the testis, respectively. Expression of the testis-specific HEMGN mRNA (HEMGN-t) is developmentally regulated and is concurrent with… CONTINUE READING

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