Alternative polyadenylation diversifies post‐transcriptional regulation by selective RNA–protein interactions

@inproceedings{Gupta2014AlternativePD,
  title={Alternative polyadenylation diversifies post‐transcriptional regulation by selective RNA–protein interactions},
  author={Ishaan Gupta and Sandra Clauder‐M{\"u}nster and Bernd Klaus and Aino I J{\"a}rvelin and Raeka S Aiyar and Vladimir Benes and Stefan Wilkening and W. Huber and Vicent Pelechano and Lars M. Steinmetz},
  booktitle={Molecular systems biology},
  year={2014}
}
Recent research has uncovered extensive variability in the boundaries of transcript isoforms, yet the functional consequences of this variation remain largely unexplored. Here, we systematically discriminate between the molecular phenotypes of overlapping coding and non-coding transcriptional events from each genic locus using a novel genome-wide, nucleotide-resolution technique to quantify the half-lives of 3' transcript isoforms in yeast. Our results reveal widespread differences in stability… CONTINUE READING
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