Alternative polyadenylation coupled to transcription initiation: Insights from ELAV-mediated 3' UTR extension.

@article{Hilgers2015AlternativePC,
  title={Alternative polyadenylation coupled to transcription initiation: Insights from ELAV-mediated 3' UTR extension.},
  author={Val{\'e}rie Hilgers},
  journal={RNA biology},
  year={2015},
  volume={12 9},
  pages={
          918-21
        }
}
Transcription initiation and mRNA maturation were long considered co-occurring but separately regulated events of gene control. In the past decade, gene promoters, the platforms of transcription initiation, have been assigned additional functions such as the regulation of splicing and 3' end processing. In a recent study, Oktaba and Zhang and al. reveal that neural 3' UTR extension is dependent on promoter sequences. In Drosophila neurons, promoter regions of a subset of genes recruit the RNA… CONTINUE READING
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