Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs.

@article{Thivierge2018AlternativePC,
  title={Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs.},
  author={Caroline Thivierge and Hsin W Tseng and Vinay K Mayya and Carine R. Lussier and Simon-Pierre Gravel and Thomas F. Duchaine},
  journal={Nucleic acids research},
  year={2018}
}
Fine regulation of the phosphatase and tensin homologue (PTEN) phosphatase dosage is critical for homeostasis and tumour suppression. The 3'-untranslated region (3'-UTR) of Pten mRNA was extensively linked to post-transcriptional regulation by microRNAs (miRNAs). In spite of this critical regulatory role, alternative 3'-UTRs of Pten have not been… CONTINUE READING