Alternative polyadenylation and miR-34 family members regulate tau expression.

  title={Alternative polyadenylation and miR-34 family members regulate tau expression.},
  author={John Robert Dickson and Carla R. Kruse and Daniel R Montagna and Bente Finsen and Michael S Wolfe},
  journal={Journal of neurochemistry},
  volume={127 6},
Tau pathologically aggregates in Alzheimer's disease, and evidence suggests that reducing tau expression may be safe and beneficial for the prevention or treatment of this disease. We sought to examine the role of the 3'-untranslated region (3'-UTR) of human tau mRNA in regulating tau expression. Tau expresses two 3'-UTR isoforms, long and short, as a result of alternative polyadenylation. Using luciferase reporter constructs, we found that expression from these isoforms is differentially… CONTINUE READING


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