Alternative pathways of polycyclic aromatic hydrocarbons activation: the formation of polar DNA adducts.

@article{BaerDubowska1999AlternativePO,
  title={Alternative pathways of polycyclic aromatic hydrocarbons activation: the formation of polar DNA adducts.},
  author={Wanda Baer-Dubowska},
  journal={Acta biochimica Polonica},
  year={1999},
  volume={46 2},
  pages={263-74}
}
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, and some are potent carcinogens in rodents. Carcinogenic PAHs are activated in the cells to metabolites that react with DNA to form covalent adducts. For most PAHs the reactive, electrophilic species which bind to DNA, are bay-region diol-epoxides. Application of 32P… CONTINUE READING