Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway

@article{Medicus1976AlternativePO,
  title={Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway},
  author={R G Medicus and Otto Goetze and HANS J. MUELLER-EBERHARD},
  journal={The Journal of Experimental Medicine},
  year={1976},
  volume={144},
  pages={1076 - 1093}
}
In this study the physiological role of properdin and the differential subunit composition of the solid phase enzymes of the pathway have been explored. Cell-bound C3 and C5 convertase differ in their C3b requirement. Apparently one molecule of C3b is sufficient to allow formation of C3 convertase (C3b,B), whereas two or more are required for generation of C5 convertase (C3bn,B). This conclusion was drawn from results indicating the critical role of the spacial distribution of C3b molecules on… CONTINUE READING