Alternative nuclear transport for cellular protein quality control.

@article{Rose2012AlternativeNT,
  title={Alternative nuclear transport for cellular protein quality control.},
  author={April E Rose and Christian Schlieker},
  journal={Trends in cell biology},
  year={2012},
  volume={22 10},
  pages={509-14}
}
Herpesvirus capsids traverse the nuclear envelope (NE) by utilizing an unusual export pathway termed nuclear egress. In this process, the viral capsid is delivered into the perinuclear space (PNS), producing a vesicular intermediate after fission. After fusion with the outer nuclear membrane (ONM), the naked capsid is released into the cytosol. A recent study now suggests that this pathway might be an endogenous cellular pathway, co-opted by viruses, that serves to transport cellular cargo… CONTINUE READING