Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.

@article{Perugini2010AlternativeMO,
  title={Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.},
  author={Michelle Perugini and Anna L. Brown and Diana G Salerno and Grant W Booker and Cvetan Stojkoski and Timothy R. Hercus and Angel F Lopez and Margaret L. Hibbs and Thomas J Gonda and Richard J. D'Andrea},
  journal={Blood},
  year={2010},
  volume={115 16},
  pages={3346-53}
}
Granulocyte/macrophage colony-stimulating factor promotes growth, survival, differentiation, and activation of normal myeloid cells and plays an important role in myeloid leukemias. The GM-CSF receptor (GMR) shares a signaling subunit, beta(c), with interleukin-3 and interleukin-5 receptors and has recently been shown to induce activation of Janus kinase 2 (JAK2) and downstream signaling via formation of a unique dodecameric receptor complex. In this study we use 2 activated beta(c) mutants… CONTINUE READING

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