Alternative mRNA polyadenylation can potentially affect detection of gene expression by affymetrix genechip arrays.

Abstract

DNA microarrays have been widely used to examine gene expression. The Affymetrix GeneChip is one of the most commonly used platforms, employing DNA probes of 25 nucleotides designed to hybridise to different regions of target mRNA. The targeted region is often biased toward the 3' end of mRNA, which can lead to biases in detection. A large number of… (More)

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Cite this paper

@article{Dmello2006AlternativeMP, title={Alternative mRNA polyadenylation can potentially affect detection of gene expression by affymetrix genechip arrays.}, author={Veera D'mello and Ju Youn Lee and Clinton C MacDonald and Bin Tian}, journal={Applied bioinformatics}, year={2006}, volume={5 4}, pages={249-53} }