Alternative lengthening of telomeres is characterized by high rates of telomeric exchange.

@article{LondooVallejo2004AlternativeLO,
  title={Alternative lengthening of telomeres is characterized by high rates of telomeric exchange.},
  author={Jos{\'e}-Arturo Londo{\~n}o-Vallejo and H Dersarkissian and Lucien Cazes and Silvia Bacchetti and Roger R Reddel},
  journal={Cancer research},
  year={2004},
  volume={64 7},
  pages={
          2324-7
        }
}
Telomere maintenance activity is a hallmark of cancer. In some telomerase-negative tumors, telomeres become lengthened by alternative lengthening of telomeres (ALT), a recombination-mediated DNA replication process in which telomeres use other telomeric DNA as a copy template. Using chromosome orientation fluorescence in situ hybridization, we found that postreplicative exchange events involving a telomere and another TTAGGG-repeat tract occur at remarkably high frequencies in ALT cells (range… CONTINUE READING

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Telomere maintenance and cancer ? look, no telomerase

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