Alternative lengthening of telomeres in normal mammalian somatic cells.

  title={Alternative lengthening of telomeres in normal mammalian somatic cells.},
  author={Axel A. Neumann and Catherine M. Watson and Jane R. Noble and Hilda A Pickett and Patrick P. L. Tam and Roger R Reddel},
  journal={Genes & development},
  volume={27 1},
Some cancers use alternative lengthening of telomeres (ALT), a mechanism whereby new telomeric DNA is synthesized from a DNA template. To determine whether normal mammalian tissues have ALT activity, we generated a mouse strain containing a DNA tag in a single telomere. We found that the tagged telomere was copied by other telomeres in somatic tissues but not the germline. The tagged telomere was also copied by other telomeres when introgressed into CAST/EiJ mice, which have telomeres more… CONTINUE READING
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