Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas

@article{Lee2015AlternativeLO,
  title={Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas},
  author={Jen-Chieh Lee and Yung-Ming Jeng and Jau-Yu Liau and J H Tsai and Hung-Han Hsu and C. Yang},
  journal={Modern Pathology},
  year={2015},
  volume={28},
  pages={1064-1073}
}
Telomerase activation and alternative lengthening of telomeres are two major mechanisms of telomere length maintenance. Soft tissue sarcomas appear to use the alternative lengthening of telomeres more frequently. Loss of α-thalassemia/mental retardation syndrome X-linked (ATRX) or death domain-associated protein 6 (DAXX) expression has been implicated in… CONTINUE READING