Alternative lengthening of telomeres: models, mechanisms and implications

@article{Cesare2010AlternativeLO,
  title={Alternative lengthening of telomeres: models, mechanisms and implications},
  author={Anthony J. Cesare and R. Reddel},
  journal={Nature Reviews Genetics},
  year={2010},
  volume={11},
  pages={319-330}
}
  • Anthony J. Cesare, R. Reddel
  • Published 2010
  • Biology, Medicine
  • Nature Reviews Genetics
  • Unlimited cellular proliferation depends on counteracting the telomere attrition that accompanies DNA replication. In human cancers this usually occurs through upregulation of telomerase activity, but in 10–15% of cancers — including some with particularly poor outcome — it is achieved through a mechanism known as alternative lengthening of telomeres (ALT). ALT, which is dependent on homologous recombination, is therefore an important target for cancer therapy. Although dissection of the… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 124 REFERENCES
    Mammalian Telomeres End in a Large Duplex Loop
    • 2,243
    • PDF
    How shelterin protects mammalian telomeres.
    • 1,536
    • PDF
    A survey of telomerase activity in human cancer.
    • 2,558