Alternative invasion pathways for Plasmodium berghei sporozoites.

  title={Alternative invasion pathways for Plasmodium berghei sporozoites.},
  author={Olivier Silvie and Jean-François Franetich and Claude Boucheix and Eric Rubinstein and Dominique Mazier},
  journal={International journal for parasitology},
  volume={37 2},
Invasion of hepatocytes by Plasmodium sporozoites is a prerequisite for establishment of a natural malaria infection. The molecular mechanisms underlying sporozoite invasion are largely unknown. We have previously reported that infection by Plasmodium falciparum and Plasmodium yoelii sporozoites depends on CD81 and cholesterol-dependent tetraspanin-enriched microdomains (TEMs) on the hepatocyte surface. Here we have analyzed the role of CD81 and TEMs during infection by sporozoites from the… CONTINUE READING
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