Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10.


Interleukin (IL)-6 signals via a receptor complex composed of the signal-transducing β-receptor gp130 and the non-signaling membrane-bound or soluble IL-6 receptor α (IL-6R, sIL-6R), which is referred to as classic and trans-signaling, respectively. IL-6 trans-signaling is functionally associated with the development of chronic inflammatory diseases and… (More)
DOI: 10.1074/jbc.M114.560938


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