Alternative folding nuclei definitions facilitate the evolution of a symmetric protein fold from a smaller peptide motif.

@article{Longo2013AlternativeFN,
  title={Alternative folding nuclei definitions facilitate the evolution of a symmetric protein fold from a smaller peptide motif.},
  author={Liam M. Longo and Jihun Lee and Connie A. Tenorio and Michael Blaber},
  journal={Structure},
  year={2013},
  volume={21 11},
  pages={
          2042-50
        }
}
Protein 3° structure symmetry is a defining feature of nearly one-third of protein folds and is generally thought to result from a combination of gene duplication, fusion, and truncation events. Such events represent major replication errors, involving substantial alteration of protein 3° structure and causing regions of exact repeating 1° structure, both of which are generally considered deleterious to protein folding. Thus, the prevalence of symmetric protein folds is counterintuitive and… CONTINUE READING
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