Alternative expression of secreted and membrane forms of immunoglobulin mu-chain is regulated by transcriptional termination in stable plasmacytoma transfectants.

@article{Guise1988AlternativeEO,
  title={Alternative expression of secreted and membrane forms of immunoglobulin mu-chain is regulated by transcriptional termination in stable plasmacytoma transfectants.},
  author={Jeffrey W. Guise and P L Lim and Dorothy Yuan and Philip W. Tucker},
  journal={Journal of immunology},
  year={1988},
  volume={140 11},
  pages={3988-94}
}
During B cell differentiation the mu H chain of IgM is produced initially as a cell surface (m) and later as a secreted (s) form. Production of either the secreted (microseconds) or the membrane (micron) mRNA results from selection of either the promoter proximal (microseconds) or distal (micron) poly(A)/cleavage site. We have transfected lymphoid cell lines of disparate developmental stages with productively rearranged Ig mu-chain constructs to determine the mechanism by which alternative 3… CONTINUE READING

Similar Papers

Loading similar papers…