Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues.

@article{Price2010AlternativeEU,
  title={Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues.},
  author={Nigel T. Price and Vicky N Jackson and J{\"u}rgen M{\"u}ller and Kevin Moffat and Karen L. Matthews and Tim Orton and Victor A. Zammit},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 11},
  pages={7857-65}
}
The Drosophila melanogaster genome contains only one CPT1 gene (Jackson, V. N., Cameron, J. M., Zammit, V. A., and Price, N. T. (1999) Biochem. J. 341, 483-489). We have now extended our original observation to all insect genomes that have been sequenced, suggesting that a single CPT1 gene is a universal feature of insect genomes. We hypothesized that insects may be able to generate kinetically distinct variants by alternative splicing of their single CPT1 gene. Analysis of the insect genomes… CONTINUE READING