Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.

@article{Boboil2010AlternativeEC,
  title={Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.},
  author={Cristian Boboilă and Mila Jankovic and Catherine T. Yan and Jing Wang and Duane R Wesemann and Tingting Christina Zhang and Alex Fazeli and Lauren Feldman and Andr{\'e} Nussenzweig and Michel C. Nussenzweig and Frederick W Alt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 7},
  pages={
          3034-9
        }
}
Class switch recombination (CSR) in B lymphocytes is initiated by introduction of multiple DNA double-strand breaks (DSBs) into switch (S) regions that flank immunoglobulin heavy chain (IgH) constant region exons. CSR is completed by joining a DSB in the donor S mu to a DSB in a downstream acceptor S region (e.g., S gamma1) by end-joining. In normal cells, many CSR junctions are mediated by classical nonhomologous end-joining (C-NHEJ), which employs the Ku70/80 complex for DSB recognition and… CONTINUE READING

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