Alternative-donor hematopoietic stem-cell transplantation for severe aplastic anemia.

@article{Margolis2000AlternativedonorHS,
  title={Alternative-donor hematopoietic stem-cell transplantation for severe aplastic anemia.},
  author={David A. Margolis and James T. Casper},
  journal={Seminars in hematology},
  year={2000},
  volume={37 1},
  pages={43-55}
}
Bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling is the treatment of choice in children and young adults with severe aplastic anemia (SAA). However, because only 30% of patients have a suitable donor, more aggressive nontransplant immunosuppressive regimens have been used, with reasonable results. The use of mismatched family member and unrelated donors, initially fraught with problems of nonengraftment and severe graft-versus-host disease (GVHD), has… CONTINUE READING