Alternative derivation for the gastrointestinal absorption residence time.

  title={Alternative derivation for the gastrointestinal absorption residence time.},
  author={Win L. Chiou and T. M. Chen and Youn-Sung Choo and M. Abdel-Hameed},
  journal={Journal of pharmaceutical sciences},
  volume={81 5},
6 Citations
The author replies to Lennernäset al.
  • W. L. Chiou
  • Chemistry
    Journal of Pharmacokinetics and Biopharmaceutics
  • 2006
Intrinsic absolute bioavailability prediction in rats based on in situ absorption rate constants and/or in vitro partition coefficients: 6-fluoroquinolones.
A preliminary study attempting to predict the intrinsic absolute bioavailability of a group of antibacterial 6-fluoroquinolones-including true and imperfect homologues as well as heterologues-was
Effect of ‘unstirred’ water layer in the intestine on the rate and extent of absorption after oral administration
  • W. L. Chiou
  • Biology
    Biopharmaceutics & drug disposition
  • 1994
The results of extensive analysis indicate that use of apparent or effective permeability rather than unbiased or true wall (membrane) permeability should generally suffice for prediction of or correlation with the fraction of oral dose absorbed after oral administration.
Intravenous verapamil kinetics in rats: Marked arteriovenous concentration difference and comparison with humans
The plasma protein binding of verapamil in humans and rats were quite similar and constant over the wide concentration range studied and the potential shortcomings of using T1/2 or CLp and the advantage of using CLu (unbound plasma clearance) in interspecies scaling is also discussed.


The Phenomenon and Rationale of Marked Dependence of Drug Concentration on Blood Sampling Site
  • W. L. Chiou
  • Medicine, Biology
    Clinical pharmacokinetics
  • 1989
The present review probably represents the first of its kind ever reported in the literature, and it is hoped that the awareness of this very fundamental and important subject matter among readers, and may also stimulate further studies or discussions.