Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages.

@article{Cashin2011AlternativeCR,
  title={Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages.},
  author={Kieran Y Cashin and Michael Roche and Jasminka Sterjovski and Anne M. Ellett and Lachlan R. Gray and Anthony L Cunningham and Paul A. Ramsland and Melissa J. Churchill and Paul R. Gorry},
  journal={Journal of virology},
  year={2011},
  volume={85 20},
  pages={10699-709}
}
Macrophage tropism of human immunodeficiency virus type 1 (HIV-1) is distinct from coreceptor specificity of the viral envelope glycoproteins (Env), but the virus-cell interactions that contribute to efficient HIV-1 entry into macrophages, particularly via CXCR4, are not well understood. Here, we characterized a panel of HIV-1 Envs that use CCR5 (n = 14) or CXCR4 (n = 6) to enter monocyte-derived macrophages (MDM) with various degrees of efficiency. Our results show that efficient CCR5-mediated… CONTINUE READING

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