Alternative clinical end points in rectal cancer--are we getting closer?

  title={Alternative clinical end points in rectal cancer--are we getting closer?},
  author={Robert Glynne-Jones and Suzannah Mawdsley and Tim Pearce and Marc Buyse},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={17 8},
BACKGROUND In rectal cancer a high risk of local recurrence has been reported for patients treated by surgery alone. It is also recognised that 20%-40% of rectal cancer patients continue to develop distant metastases and die, even when a very low risk of local recurrence has been achieved with the use of preoperative radiotherapy and total mesorectal excision (TME). Hence, the current design of randomised trials in rectal cancer continues to use the standard end points of local control and… CONTINUE READING


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