Alternative cleavage and polyadenylation during colorectal cancer development.

@article{Morris2012AlternativeCA,
  title={Alternative cleavage and polyadenylation during colorectal cancer development.},
  author={Adam Remy Morris and Arnold J. Bos and Bego{\~n}a Diosdado and Koos Rooijers and Ran Elkon and Anne S. Bolijn and Beatriz Nozari Ribeiro de Carvalho and G A Meijer and Reuven Agami},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 19},
  pages={5256-66}
}
PURPOSE Alternative cleavage and polyadenylation (APA) of mRNAs is a phenomenon that alters 3'-untranslated region length leading to altered posttranscriptional regulation of gene expression. Changing APA patterns have been shown to result in misregulation of genes involved in carcinogenesis; therefore, we hypothesized that altered APA contributes to progression of colorectal cancer, and that measurement of APA may lead to discovery of novel biomarkers. EXPERIMENTAL DESIGN We used next… CONTINUE READING
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