Alternative cleavage and polyadenylation during colorectal cancer development.

  title={Alternative cleavage and polyadenylation during colorectal cancer development.},
  author={Adam Remy Morris and Arnold J. Bos and Bego{\~n}a Diosdado and Koos Rooijers and Ran Elkon and Anne S. Bolijn and Beatriz Nozari Ribeiro de Carvalho and G A Meijer and Reuven Agami},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={18 19},
PURPOSE Alternative cleavage and polyadenylation (APA) of mRNAs is a phenomenon that alters 3'-untranslated region length leading to altered posttranscriptional regulation of gene expression. Changing APA patterns have been shown to result in misregulation of genes involved in carcinogenesis; therefore, we hypothesized that altered APA contributes to progression of colorectal cancer, and that measurement of APA may lead to discovery of novel biomarkers. EXPERIMENTAL DESIGN We used next… CONTINUE READING
Highly Cited
This paper has 235 citations. REVIEW CITATIONS

5 Figures & Tables



Citations per Year

235 Citations

Semantic Scholar estimates that this publication has 235 citations based on the available data.

See our FAQ for additional information.