Alternative cell death mechanisms in development and beyond.

  title={Alternative cell death mechanisms in development and beyond.},
  author={Junying Yuan and Guido Kroemer},
  journal={Genes & development},
  volume={24 23},
A canonical regulatory pathway involving the members of the Bcl-2 and caspase families has been established to regulate developmental apoptosis in nematodes and flies. However, mutant mice that have major deficiencies in this apoptosis pathway show only relatively minor developmental defects. Recent revelations indicate that multiple mechanisms are involved in regulating cell death during mammalian development, tissue homeostasis, and pathological cell loss. Here, we critically evaluate the… CONTINUE READING