Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity.

@article{Maurus2008AlternativeCA,
  title={Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity.},
  author={Robert Maurus and A. Sabeena Begum and L. Katherine Williams and Jason R Fredriksen and Ran Zhang and Stephen G Withers and Gary D. Brayer},
  journal={Biochemistry},
  year={2008},
  volume={47 11},
  pages={3332-44}
}
A mechanistic study of the essential allosteric activation of human pancreatic alpha-amylase by chloride ion has been conducted by exploring a wide range of anion substitutions through kinetic and structural experiments. Surprisingly, kinetic studies indicate that the majority of these alternative anions can induce some level of enzymatic activity despite very different atomic geometries, sizes, and polyatomic natures. These data and subsequent structural studies attest to the remarkable… CONTINUE READING
10 Citations
31 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Similar Papers

Loading similar papers…