Alternative approaches to the discovery and development of telomerase-targeted anticancer drugs.

Abstract

Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site; ii) miscellaneous molecules with unknown mechanism(s) of action; iii) inhibitors of upstream processes of regulation of the hTERT subunit; iiii) immunotherapy against immunogenic hTERT-derived peptides.

Cite this paper

@article{Richter2003AlternativeAT, title={Alternative approaches to the discovery and development of telomerase-targeted anticancer drugs.}, author={Sara N Richter and Manlio Palumbo}, journal={Mini reviews in medicinal chemistry}, year={2003}, volume={3 1}, pages={37-49} }