Alternative analyses for handling incomplete follow-up in the intention-to-treat analysis: the randomized controlled trial of balloon kyphoplasty versus non-surgical care for vertebral compression fracture (FREE)

@inproceedings{Ranstam2012AlternativeAF,
  title={Alternative analyses for handling incomplete follow-up in the intention-to-treat analysis: the randomized controlled trial of balloon kyphoplasty versus non-surgical care for vertebral compression fracture (FREE)},
  author={Jonas Ranstam and Aleksandra Turkiewicz and Steven Boonen and Jan Van Meirhaeghe and Leonard Bastian and Douglas Wardlaw},
  booktitle={BMC medical research methodology},
  year={2012}
}
BACKGROUND Clinical trial participants may be temporarily absent or withdraw from trials, leading to missing data. In intention-to-treat (ITT) analyses, several approaches are used for handling the missing information - complete case (CC) analysis, mixed-effects model (MM) analysis, last observation carried forward (LOCF) and multiple imputation (MI). This report discusses the consequences of applying the CC, LOCF and MI for the ITT analysis of published data (analysed using the MM method) from… CONTINUE READING
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