Alternative analyses for handling incomplete follow-up in the intention-to-treat analysis: the randomized controlled trial of balloon kyphoplasty versus non-surgical care for vertebral compression fracture (FREE)

Abstract

BACKGROUND Clinical trial participants may be temporarily absent or withdraw from trials, leading to missing data. In intention-to-treat (ITT) analyses, several approaches are used for handling the missing information - complete case (CC) analysis, mixed-effects model (MM) analysis, last observation carried forward (LOCF) and multiple imputation (MI). This… (More)
DOI: 10.1186/1471-2288-12-35

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Cite this paper

@inproceedings{Ranstam2012AlternativeAF, title={Alternative analyses for handling incomplete follow-up in the intention-to-treat analysis: the randomized controlled trial of balloon kyphoplasty versus non-surgical care for vertebral compression fracture (FREE)}, author={Jonas Ranstam and Aleksandra Turkiewicz and Steven Boonen and Jan Van Meirhaeghe and Leonard Bastian and Douglas Wardlaw}, booktitle={BMC medical research methodology}, year={2012} }