Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure

@article{Murthy2015AlternativeAO,
  title={Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure},
  author={Shubha Murthy and Jennifer L. Larson-Casey and Alan J Ryan and Chao He and Lester Kobzik and A Brent Carter},
  journal={The FASEB Journal},
  year={2015},
  volume={29},
  pages={3527 - 3536}
}
Alternative activation of alveolar macrophages is linked to fibrosis following exposure to asbestos. The scavenger receptor, macrophage receptor with collagenous structure (MARCO), provides innate immune defense against inhaled particles and pathogens; however, a receptor for asbestos has not been identified. We hypothesized that MARCO acts as an initial signaling receptor for asbestos, polarizes macrophages to a profibrotic M2 phenotype, and is required for the development of asbestos‐induced… Expand
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