Alternative Splicing in Neurogenesis and Brain Development

  title={Alternative Splicing in Neurogenesis and Brain Development},
  author={Chun-Hao Su and Dhananjaya D and Woan-Yuh Tarn},
  journal={Frontiers in Molecular Biosciences},
Alternative splicing of precursor mRNA is an important mechanism that increases transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA levels. Alternative splicing occurs at high frequency in brain tissues and contributes to every step of nervous system development, including cell-fate decisions, neuronal migration, axon guidance, and synaptogenesis. Genetic manipulation and RNA sequencing have provided insights into the molecular mechanisms underlying the effects… 

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