Alternative Splicing and Subfunctionalization Generates Functional Diversity in Fungal Proteomes

@inproceedings{Marshall2013AlternativeSA,
  title={Alternative Splicing and Subfunctionalization Generates Functional Diversity in Fungal Proteomes},
  author={Alexandra N. Marshall and Maria Camila Montealegre and Claudia Jim{\'e}nez-L{\'o}pez and Michael C Lorenz and Ambro van Hoof},
  booktitle={PLoS genetics},
  year={2013}
}
Alternative splicing is commonly used by the Metazoa to generate more than one protein from a gene. However, such diversification of the proteome by alternative splicing is much rarer in fungi. We describe here an ancient fungal alternative splicing event in which these two proteins are generated from a single alternatively spliced ancestral SKI7/HBS1 gene retained in many species in both the Ascomycota and Basidiomycota. While the ability to express two proteins from a single SKI7/HBS1 gene is… CONTINUE READING
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