Alternative Splice Transcripts for MHC Class I-like MICA Encode Novel NKG2D Ligands with Agonist or Antagonist Functions.

@article{Gavlovsky2016AlternativeST,
  title={Alternative Splice Transcripts for MHC Class I-like MICA Encode Novel NKG2D Ligands with Agonist or Antagonist Functions.},
  author={Pierre-Jean Gavlovsky and Pierre Tonnerre and Nathalie G{\'e}rard and Steven N{\'e}dellec and Andrew W Daman and Benjamin J McFarland and B{\'e}atrice Charreau},
  journal={Journal of immunology},
  year={2016},
  volume={197 3},
  pages={736-46}
}
MHC class I chain-related proteins A and B (MICA and MICB) and UL16-binding proteins are ligands of the activating NKG2D receptor involved in cancer and immune surveillance of infection. Structurally, MICA/B proteins contain an α3 domain, whereas UL16-binding proteins do not. We identified novel alternative splice transcripts for MICA encoding five novel… CONTINUE READING