Alternative Splice Transcripts for MHC Class I-like MICA Encode Novel NKG2D Ligands with Agonist or Antagonist Functions.

Abstract

MHC class I chain-related proteins A and B (MICA and MICB) and UL16-binding proteins are ligands of the activating NKG2D receptor involved in cancer and immune surveillance of infection. Structurally, MICA/B proteins contain an α3 domain, whereas UL16-binding proteins do not. We identified novel alternative splice transcripts for MICA encoding five novel… (More)
DOI: 10.4049/jimmunol.1501416

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Cite this paper

@article{Gavlovsky2016AlternativeST, title={Alternative Splice Transcripts for MHC Class I-like MICA Encode Novel NKG2D Ligands with Agonist or Antagonist Functions.}, author={Pierre-Jean Gavlovsky and Pierre Tonnerre and Nathalie G{\'e}rard and Steven N{\'e}dellec and Andrew W Daman and Benjamin J McFarland and B{\'e}atrice Charreau}, journal={Journal of immunology}, year={2016}, volume={197 3}, pages={736-46} }