Alternative Runx1 promoter usage in mouse developmental hematopoiesis.

  title={Alternative Runx1 promoter usage in mouse developmental hematopoiesis.},
  author={Thomas Bee and Kate Liddiard and Gemma Swiers and Sorrel R. B. Bickley and Chris S Vink and Andrew Jarratt and Jim R. Hughes and Alexander Medvinsky and Marella Ftr de Bruijn},
  journal={Blood cells, molecules & diseases},
  volume={43 1},
The interest in stem cell based therapies has emphasized the importance of understanding the cellular and molecular mechanisms by which stem cells are generated in ontogeny and maintained throughout adult life. Hematopoietic stem cells (HSCs) are first found in clusters of hematopoietic cells budding from the luminal wall of the major arteries in the developing mammalian embryo. The transcription factor Runx1 is critical for their generation and is specifically expressed at sites of HSC… CONTINUE READING


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