Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice

@inproceedings{Hung2016AlternativeRO,
  title={Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice},
  author={Yi-Han Hung and Wen-Yeh Hsieh and Jih-Sheng Hsieh and F Liu and Chin-Hung Tsai and Li-Che Lu and Chen-yi Huang and Chien-Liang Wu and Chih-Sheng Lin},
  booktitle={International journal of biological sciences},
  year={2016}
}
Inflammation-mediated abnormalities in the renin-angiotensin system (RAS) and expression of matrix metalloproteinases (MMPs) are implicated in the pathogenesis of lung injury. Angiotensin converting enzyme II (ACE2), an angiotensin converting enzyme (ACE) homologue that displays antagonist effects on ACE/angiotensin II (Ang II) axis, could also play a protective role against lung diseases. However, the relationship between ACE2 and MMPs activation in lung injury is still largely unclear. The… CONTINUE READING

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