Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

@article{Amara1982AlternativeRP,
  title={Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products},
  author={Susan G. Amara and Vivian Jonas and Michael G. Rosenfeld and Estelita Sebastian Ong and Ronald M. Evans},
  journal={Nature},
  year={1982},
  volume={298},
  pages={240-244}
}
Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene… 

Alternative RNA processing events gene-related peptide gene expressi (neuroendocrine/pituitary/RNA processing/hormone precursor)

It is suggested that both the calcitonin and CGRP exons arose from a common primordial sequence, suggesting that duplication and rearrangement events are responsible for the generation of this complex transcription unit.

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.

Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide.

An intron element residing in intron 4 of the human CT/CGRP gene is identified and characterized and functions to enhance polyadenylation of an embedded alternative 3'-terminal exon within theCT/C GRP gene and is potentially involved in tissue-specific regulation of CT/ CGRP RNA processing.

RNA processing regulation of neuroendorcrine gene expression.

The selective use of alternative hormone-encoding exons can produce multiple mRNAs generating different protein products and the resultant "peptide switching" is a previously unrecognized mechanism allowing a single gene to encode different hormones in different tissues and thus increases the diversity of endocrine gene expression.

Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor

It is suggested that the tissue-specific pattern of alternative RNA processing is conferred by sequence information at the calcitonin-specific acceptor which serves to inhibit the production of calcitonIn transcripts in CGRP-producing cells.

Alternative RNA processing – its role in regulating expression of calcitonin/calcitonin gene-related peptide

This intron element functions to enhance polyadenylation of an embedded alternative 3 (cid:42) -terminal exon within the CT/ CGRP gene and is potentially involved in tissue-specific regulation of CT/CGRP RNA processing.

Alternative RNA processing: determining neuronal phenotype.

The distribution of CGRP in the central and peripheral nervous system and in endocrine and other organ systems suggests potential functions in nociception, ingestive behavior, cardiovascular homeostasis, and mineral metabolism.

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites

Different 3' coding exons in the rat calcitonin gene are used to generate distinct mRNAs encoding either the hormone calcitonin in thyroidal C-cells or a new neuropeptide referred to as calcitonin
...

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    Proceedings of the National Academy of Sciences of the United States of America
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