Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

@article{Amara1982AlternativeRP,
  title={Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products},
  author={S. Amara and V. Jonas and M. Rosenfeld and E. Ong and R. Evans},
  journal={Nature},
  year={1982},
  volume={298},
  pages={240-244}
}
  • S. Amara, V. Jonas, +2 authors R. Evans
  • Published 1982
  • Biology, Medicine
  • Nature
    • Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene… CONTINUE READING
    View on Nature
    ncbi.nlm.nih.gov
    1,861 Citations
    Highly Influencial Citations
    22
    Background Citations
    361
    Methods Citations
    20
    Results Citations
    2
    1,861 Citations
    Citation Type

    Citation Type

    Alternative RNA processing events gene-related peptide gene expressi (neuroendocrine/pituitary/RNA processing/hormone precursor)
    Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
    • 2,123
    Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression
    • 130
    Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide.
    • 47
    • PDF
    RNA processing regulation of neuroendorcrine gene expression.
    • 7
    Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor
    • 113
    The two mature transcripts of the chick calcitonin gene are expressed within the central nervous system during embryogenesis
    • 5
    Alternative RNA processing: determining neuronal phenotype.
    • 206
    Sequence and expression of the chicken calcitonin gene
    • 28
    Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.
    • 92

    References

    SHOWING 1-10 OF 33 REFERENCES
    Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events.
    • M. Rosenfeld, C. Lin, +4 authors R. Evans
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1982
    • 90
    • PDF
    Calcitonin messenger RNA encodes multiple polypeptides in a single precursor.
    • 111
    Altered expression of the calcitonin gene associated with RNA polymorphism
    • 84
    Characterization of rat calcitonin mRNA.
    • 65
    • PDF
    Thyrotropin-releasing hormone exerts rapid nuclear effects to increase production of the primary prolactin mRNA transcript.
    • 55
    • PDF
    Multiple polyadenylation sites in a mouse α-amylase gene
    • 96
    Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways
    • 648
    Calcitonin COOH-terminal cleavage peptide as a model for identification of novel neuropeptides predicted by recombinant DNA analysis.
    • 33
    • PDF
    Transcription and RNA processing by the DNA tumour viruses
    • 145
    Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor
    • 1,557