Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

@article{Amara1982AlternativeRP,
  title={Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products},
  author={S. Amara and V. Jonas and M. Rosenfeld and E. Ong and R. Evans},
  journal={Nature},
  year={1982},
  volume={298},
  pages={240-244}
}
  • S. Amara, V. Jonas, +2 authors R. Evans
  • Published 1982
  • Biology, Medicine
  • Nature
  • Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene… CONTINUE READING
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