Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
@article{Amara1982AlternativeRP, title={Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products}, author={S. Amara and V. Jonas and M. Rosenfeld and E. Ong and R. Evans}, journal={Nature}, year={1982}, volume={298}, pages={240-244} }
Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene… CONTINUE READING
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